Skip to main content
. 2021 Nov 23;97(21):e2065–e2078. doi: 10.1212/WNL.0000000000012853

Figure 5. Association of CSF Synaptic Biomarkers With Cortical MRI AD Signature.

Figure 5

Scatter plots representing the association of each of the CSF synaptic biomarker with the cortical thickness (millimeters) Alzheimer disease (AD) signature in the CSF β-amyloid (Aβ)–negative (A−; blue) and the CSF Aβ-positive (A+; red) groups. CSF Aβ status was defined by the CSF Aβ42/40 ratio, and participants were classified as CSF Aβ-positive if CSF Aβ42/40 <0.071. Each point depicts the value of the CSF biomarker of an individual, and the solid lines indicate the regression line for each of the groups. The associations were computed with a linear model adjusted for age and sex. GAP-43 = growth-associated protein-43; SNAP-25 = synaptosomal-associated protein-25.