|
• Clarke et al perform the first randomized prospective placebo blinded clinical trial demonstrating that oral antibiotics prevent anastomotic leak following colon surgery
13
|
|
• Komen et al demonstrate that early postoperative detection by reverse transcription polymerase chain reaction (RT-PCR) for
Enterococcus faecalis
in intra-abdominal drains may be an affordable screening tool for anastomotic leak
20
|
|
• Schardey et al performs a randomized prospective controlled trial of oral antibiotics in upper gastrointestinal surgery demonstrating that oral antibiotics decrease anastomotic leak rates
14
|
|
• Retrospective studies mining large databases within the NSQIP (National Surgical Quality Improvement Program) demonstrate that oral antibiotics decrease rates of anastomotic leak
15
|
|
• Studies from Korea demonstrate that the two most common organism isolated from sites of anastomotic leak are
E. faecalis
and
Pseudomonas aeruginosa
, the two highest collagenase producing organisms in the gastrointestinal tract
19
|
|
• Wirth performs a study demonstrating that local anastomotic decontamination of the colon anastomosis with topical antibiotics (via enema) decrease anastomotic leak rates
16
|
|
• Prospective randomized controlled clinical trial from Europe demonstrates that mechanical bowel prep and oral antibiotics reduces anastomotic leak rates
17
|
