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. 2021 Nov 19;14:6067–6083. doi: 10.2147/JIR.S339382

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© 2021 Jin et al.

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FSS results in H3K4me3 activation and KMT2B upregulation. (A) Western blot results of H3K4me3, H3K9me3, H3K27me3, H3K36me3,and H3K79me3 expression in chondrocytes exposed to FSS. (B) Immunofluorescent staining of H3K4me3 in chondrocytes after FSS treatment. (C) The mRNA level of H3K4 methyltransferases in chondrocytes under static or FSS conditions. (D) The protein expression of KMT2B was significantly upregulated after FSS treatment. Scar bar, 50 μm. **p < 0.01, ns, not significant.