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. 2021 Nov 19;14:6067–6083. doi: 10.2147/JIR.S339382

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© 2021 Jin et al.

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Pharmacological inhibition of H3K4me3 activation by MM-102 partially rescues the negative effect of FSS on chondrocytes. (A) Pretreatment of MM-102 in primary chondrocytes could alleviate SNP-induced apoptosis activities. (B) qPCR results indicated the inhibition of H3K4me3 activation by MM-102 partially rescues the negative effect of FSS on chondrocytes. (C) Western blot results of COLII, SOX9, COX-2, and MMP13 in chondrocytes exposed to FSS with or without MM-102 pretreatment. *p < 0.05, **p < 0.01, ***p < 0.001.