Table 2.
The expression levels (mean RQ value) of the studied genes and miRNAs in the COPD and control group in induced sputum.
| COPD group (mean RQ value ± SD) | Control group (mean RQ value) | p value | |
|---|---|---|---|
| General cohort | |||
| Genes | |||
| IL-6 | 0.259 ± 0.697 | 0.304 ± 0.251 | 0.0008* |
| IL6ST | 0.191 ± 0.204 | 0.113 ± 0.09 | 0.05* |
| PIAS3 | 0.554 ± 1.73 | 0.188 ± 0.100 | 0.19 |
| STAT3 | 0.941 ± 1.065 | 0.758 ± 0.596 | 0.61 |
| miRNA | |||
| miRNA-1 | 0.531 ± 1.361 | 0.211 ± 0.450 | 0.99 |
| miRNA-106b | 11.21 ± 11.733 | 6.49 ± 6.08 | 0.15 |
| miRNA-155 | 154.78 ± 380.54 | 94.29 ± 162.05 | 0.25 |
| Current smokers | |||
| Genes | |||
| IL-6 | 0.442 ± 0.874 | 0.334 ± 0.293 | 0.12 |
| IL6ST | 0.163 ± 0.155 | 0.106 ± 0.08 | 0.39 |
| PIAS3 | 0.288 ± 0.549 | 0.171 ± 0.075 | 0.11 |
| STAT3 | 1.05 ± 0.850 | 0.607 ± 0.661 | 0.09 |
| miRNA | |||
| miRNA-1 | 0.649 ± 1.590 | 0.204 ± 0.522 | 0.42 |
| miRNA-106b | 8.826 ± 11.368 | 6.08 ± 5.34 | 0.87 |
| miRNA-155 | 293.349 ± 542.342 | 147.195 ± 194.168 | 0.49 |
| Ex-smokers | |||
| Genes | |||
| IL-6 | 0.187 ± 0.527 | 0.260 ± 0.180 | 0.008* |
| IL6ST | 0.212 ± 0.234 | 0.123 ± 0.119 | 0.16 |
| PIAS3 | 0.750 ± 2.23 | 0.214 ± 0.129 | 0.60 |
| STAT3 | 0.859 ± 1.235 | 0.890 ± 0.494 | 0.35 |
| miRNA | |||
| miRNA-1 | 0.444 ± 1.195 | 0.222 ± 0.349 | 0.66 |
| miRNA-106b | 12.979 ± 11.934 | 7.11 ± 7.40 | 0.19 |
| miRNA-155 | 52.322 ± 130.316 | 14.94 ± 6.46 | 0.06 |
*Statistically significant differences p < 0.005.