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. 2021 Nov 23;12:6791. doi: 10.1038/s41467-021-27097-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic drawing of renin-angiotensin system (RAS) and ACE2 in lung injury. Downregulation of ACE2 expression in SARS-CoV-2 infection is implicated by the studies on SARS coronavirus. b, c Protein expression of ACE2 in hamster lungs at 4 days after intranasal infection of SARS-CoV-2. Western blot of lung lysates from the hamsters infected with SARS-CoV-2 (UT-NCGM02) (b) are shown. NP Nucleocapsid phosphoprotein. * unfolded or short form of ACE2 or non-specific band. Infection with the HKU-001a strain is shown in Supplementary Fig. 1b. Quantification of ACE2 protein abundance (c) was done with combined results of the two virus strains; uninfected control (n = 8) and SARS-CoV-2 infection (n = 11). Values are means ± SEM. Two-tailed unpaired t-test. Independent experiments were performed one time (b) or two times (c), and consistent results were obtained.