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. 2021 Nov 23;11:22764. doi: 10.1038/s41598-021-02262-7

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of SCG2 concentration in clinical serum samples. SCG2 concentration in serum samples of patients and control groups was analyzed with enhanced nanoplasmonic immunosensor (E-NPIS) (A) and ELISA (B). The serum samples were 1:10 diluted (E-NPIS) or 1:5 diluted (ELISA) with PBS buffer. Data represent the means ± s.d. of three replicates from 5 controls and 8 patients for E-NPIS analysis, 2 controls and 6 patients for ELISA analysis. SCG2 concentration was below the LOD of ELISA for some clinical samples. P = 0.089 for E-NPIS and p = 0.383 for ELISA (Student’s t-test). Basic information of clinical serum samples was described in Table S1 (Supplementary information).