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. 2021 Nov 23;11:22764. doi: 10.1038/s41598-021-02262-7

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dendritic arborization and synaptic formation attenuated by SCG2 overexpression. (A) Attenuated dendritic arborization by SCG2 overexpression. Rat hippocampal neurons were transfected with human SCG2 clone (hSCG2) (Fig. S1B). The numbers of dendrites and arborization significantly decreased after SCG2 overexpression (SCG2 OE) as compared with that in the control group that expressed EGFP only (Cont). Means $\pm$ s.e.m. of data from 10 control neurons (Cont) and 10 hSCG2 neurons (SCG2 OE) are shown. For primary dendrites: ***p < 0.001; for secondary dendrites: ***p < 0.001; for Sholl analysis of arborization: *p < 0.05, **p < 0.01, and ***p < 0.001 (Student’s t-test). Scale bar: 50 μm. (B–D) Decreased synaptic formation by overexpression of SCG2. The density of dendritic spines and the numbers of excitatory and inhibitory synapses significantly decreased after SCG2 overexpression (SCG2 OE) as compared with that in the control group (Cont). Means $\pm$ s.e.m. of data from 28 dendrites of 7 control neurons (Cont) and 28 dendrites of 7 hSCG2 neurons (SCG2 OE). (B) The density of dendritic spines: *p < 0.05. (C) The numbers of excitatory synapses: *p < 0.05. (D) The numbers of inhibitory synapses: **p < 0.01 (Student’s t-test). Scale bar: 10 μm.