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. 2021 Nov 23;11:22755. doi: 10.1038/s41598-021-01987-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of nucleoid distribution analysis by Mitomate tracker. Confocal live cell Images of mitochondria (TMRM, red) and nucleoids (Picogreen, green—nucleus manually removed) are analyzed using Mitomate tracker. Mitochondria are segmented and their components are identified using Momito while nucleoids are identified using the Image J Plugin Trackmate. The information extracted from Momito and Trackmate is then analyzed by the R package spatstat. Mitomate Tracker provides detailed descriptors of network and nucleoid features and measures nucleoid distribution pattern by two metrics, the nearest neighbor distance (nndist) and the pair correlation function (pcf).