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. 2021 Nov 23;6:77. doi: 10.1038/s41536-021-00187-3

Fig. 3. Focal articular cartilage defects treated with hESDC-M show improved repair at 6 months.

Fig. 3

a Gross visual appearance of all 10 defects created in the femoral condyle of control (membrane alone, top row) or treated (hESDC-M, bottom row) Yucatan minipig knees after 6 months. Scale bar = 10 mm. b Safranin O/Fast Green staining of the interface between the graft and endogenous tissue or the defect itself (boxes); where the boxed regions are shown at higher magnification below. Scale bar = 100 μm. c Histological scoring of sections from control and treated femoral condyles for the 14 parameters comprising the ICRS II cartilage repair scoring system (left); each point represents the average of both defects per animal. (Right) Aggregate score of all 14 parameters over the 10 defects scored. Identifiers above or under images represent each animal. p-value was calculated using unpaired Student’s t-test; data presented as mean ± SD.