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. 2021 Nov 23;12(12):1100. doi: 10.1038/s41419-021-04390-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A, B Trajectory analysis revealing the retinoblastoma cells progression, colour-coded according to cell clusters (all three subtypes of retinoblastoma cells). C Pseudotime trajectory analysis of individual clusters (c4, c5, c10). D Feature expression heatmap showing expression patterns of select markers across three retinoblastoma cell clusters. The size of each circle depicts the percentage of cells expressing the marker within the cluster. Purple colour indicated the average expression (number of transcripts). E Heatmap displaying normalized expression of top 10 DEGs among three subtypes of retinoblastoma cells (c4, c5, c10). F Heatmap of KEGG enrichment analysis enrichment by clusters (c4, c5, c10).