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. 2021 Nov 23;12(12):1100. doi: 10.1038/s41419-021-04390-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Trajectory reconstruction of all single cells throughout chemical reprogramming reveals three branches: pre-branch (before bifurcation), successful branch, and failed branch (after bifurcation). Blue and red circles indicate cells of the successful and failed branches, respectively. B Heatmap showing the top 40 DEGs expression levels in successful branch and failed branch cells. C Protein-protein interaction network of the top 40 DEGs in successful branch. D Heatmap showing the select genes expression dynamics during the cellular-state transition process and expression dynamics. The successful and failed branches reprogramming trajectories (including pre-branch) are shown on the right and left, respectively.