Table 2.
General characteristics of the subjects enrolled in the study cohort.
| Patients diagnosed with sepsis n = 33 |
Healthy volunteers n = 19 |
p-values | |
|---|---|---|---|
| Age (years) ⁎ | 68 (57.5–73) | 71.5 (64–76.5) | 0.086 |
| Sex, male/female, n | 20/13 | 7/12 | 0.150 |
| APACHE II score⁎ | 26 (20–35) | N/A | ND |
| SOFA score ⁎ | 8 (5–11) | N/A | ND |
| Rate of in-hospital death, n (%) | 9 (27) | N/A | ND |
| Types of admission, n (%) | ND | ||
| Medical | 27 (82) | N/A | ND |
| Emergency surgery | 6 (18) | N/A | ND |
| Sepsis category, n (%) | ND | ||
| Sepsis/septic shock | 21 (64) | N/A | ND |
| Refractory septic shock | 12 (36) | N/A | ND |
| Types of infection, n | |||
| Pneumonia | 13 | N/A | ND |
| Urosepsis | 8 | N/A | ND |
| Fasciitis | 5 | N/A | ND |
| Cholangitis | 2 | N/A | ND |
| Mediastinitis | 2 | N/A | ND |
| Peritonitis | 2 | N/A | ND |
| Colitis | 1 | N/A | ND |
| Esophageal-pleural perforation | 1 | N/A | |
| Blood PMN counts (109/L) | 20.6 ± 3.3 | 10.1 ± 1.5 | < 0.0001‡ |
| Blood band cells (%) ⁎ | 1.2 (0.6–3.6) | 0.05 (0–0.125) | < 0.0001‡ |
| PMN CD64 expression (MFI) ⁎ | 407 (271–560) | 179 (159–246) | < 0.0001‡ |
| Pentraxin 3 (ng/mL) ⁎ | 8 (6–20) | 2 (1–3) | 0.032‡ |
| Lactate (mmol/L) † | 4.55 ± 3.7 | N/A | ND |
| Plasma cortisol level (nmol/L) † | 1176 (774–1750) | N/A | ND |
Data are expressed as the median [25–75 interquartile range] or mean ± SD †, as appropriate. The Mann–Whitney U test was used to compare age, and Fisher’s exact test was used for contingency in sex-based comparisons. Biological data were analyzed by Student’s t-test or the Mann–Whitney U test. There were four, five and two missing data points for CD64, PTX3, and cortisol measurements, respectively.
N/A not applicable, ND not determined, APACHE II Admission Acute Physiology and Chronic Health Evaluation II, SOFA Sequential Organ Failure Assessment, PMN polymorphonuclear neutrophil, MFI mean fluorescence intensity.