Table 2.
Characteristics of ovarian stimulation, oocyte retrieval, fertilization, embryo development and embryo freezing.
| Characteristics | Corifollitropin alfa/PPOS protocol (n = 173) | Corifollitropin alfa/GnRHant protocol (n = 160) | P value |
|---|---|---|---|
| Stimulation | |||
| Duration of GnRHant injections (days) | 0 ± 0 | 6.8 ± 1.4 | 0.000 |
| Duration of additional gonadotropin stimulation (days) | 3.9 ± 1.3 | 3.8 ± 1.4 | 0.240 |
| Total dose of additional gonadotropin consumption (IU) | 497.7 ± 233.1 | 478.4 ± 301.8 | 0.511 |
| Average dose of additional daily gonadotropin consumption (IU) | 124.3 ± 32.6 | 120.7 ± 36.9 | 0.344 |
| Serum hormonal level on ovulation trigger day | |||
| E2 (pg/mL) | 7694.5 ± 3219.5 | 7829.9 ± 3266.1 | 0.704 |
| LH (IU/L) | 1.5 ± 1.2 | 1.3 ± 1.0 | 0.242 |
| Progesterone (ng/mL) | 2.1 ± 0.9 | 2.0 ± 0.9 | 0.589 |
| Incidence of premature LH surge (%) | 0 (0/173) | 0 (0/160) | |
| Incidence of OHSS (%) | 0 (0/173) | 0 (0/160) | |
| Oocyte retrieval | |||
| No. of oocytes retrieved | 20.7 ± 6.3 | 19.8 ± 6.2 | 0.195 |
| Metaphase II oocyte rate (%) | 78.8 ± 15.0 | 78.1 ± 15.8 | 0.688 |
| Fertilization rate (%) | 73.9 ± 16.7 | 73.6 ± 17.7 | 0.883 |
| Embryo development (day 5/6) | |||
| No. of good blastocyst | 4.1 ± 3.0 | 4.0 ± 3.1 | 0.673 |
| No. of blastocyst frozen | 6.9 ± 4.8 | 6.7 ± 4.8 | 0.655 |
Values are expressed as either mean ± standard deviation or percentage. PPOS progestin primed ovarian stimulation, GnRHant GnRH antagonist, E2 estradiol, LH luteinizing hormone, OHSS ovarian hyperstimulation syndrome.