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. 2021 Nov 23;11:22729. doi: 10.1038/s41598-021-02163-9

Table 5.

Association between place of residence and manifestation of certain clinical signs.

Clinical sign Unexposed region (Carhuamayo)
N (%)
Exposed region (Paragsha)
N (%)
Odds ratio Odds ratio
p-value
History of nosebleed
No 14 (87.5) 29 (37.2) 15.40  < 0.001
Yes 2 (12.5) 49 (62.8)
White lines on nails
No 16 (100) 51 (65.4) 12.10 0.001
Yes 0 (0.0) 27 (34.6)
Chronic colic
No 15 (93.8) 49 (62.8) 7.30 0.007
Yes 1 (6.2) 29 (37.2)
Dermatologic alterations
No 16 (100) 63 (80.8) 6.16 0.013
Yes 0 (0) 15 (19.2)
Mood alterations
No 16 (100) 61 (78.2) 7.07 0.008
Yes 0 (0) 17 (21.8)
Constipation
No 16 (100) 64 (82.1) 5.71 0.017
Yes 0 (0) 14 (17.9)
Reduced visual field
No 16 (100) 68 (97.2) 3.97 0.046
Yes 0 (0) 10 (12.8)
Other clinical symptoms
No 15 (93.8) 54 (69.2) 5.12 0.024
Yes 1 (6.2) 24 (30.8)

N number of children, X2 chi-square test.

Dermatologic alterations include café-au-lait spots in flexor areas of the abdomen, back, chest or neck, calluses on palms of the hands, soles with thick and rough skin and calluses in areas without friction; other clinical symptoms encompassed bluish line on the gum, calluses in body areas without friction, calluses on palms and sole with thick and rough skin and inflamed conjunctiva.