Table 1.
Top 10 diseases and functions associated with the top disrupted networks in vapers and smokers, respectively, as illustrated in Fig. 5A,B.
| Categories | Diseases or functions annotation | P-value | Molecules | # Molecules | |
|---|---|---|---|---|---|
| Vapers | Hereditary disorder, metabolic disease, neurological disease, organismal injury and abnormalities, psychological disorders, skeletal and muscular disorders | MELAS syndrome | 4.71E-13 | MT-TI, MT-TK, MT-TL2, MT-TM, MT-TQ | 5 |
| Metabolic disease, organismal injury and abnormalities | Mitochondrial DNA-related disorder | 5.05E-12 | Mitochondrial complex 1, MT-RNR1, MT-TI, MT-TK, MT-TL2, MT-TM, MT-TQ | 7 | |
| Gene expression | Elongation of mRNA | 6.67E-12 | MT-TI, MT-TK, MT-TL2, MT-TM, MT-TQ | 5 | |
| Metabolic disease, neurological disease, organismal injury and abnormalities, skeletal and muscular disorders | Mitochondrial cytopathy | 6.43E-09 | Mitochondrial complex 1, MT-TI, MT-TK, MT-TL2, MT-TM, MT-TQ | 6 | |
| Hereditary disorder, organismal injury and abnormalities, skeletal and muscular disorders | Hereditary myopathy | 9.99E-09 | CALD1, MT-RNR1, MT-TI, MT-TK, MT-TL2, MT-TM, MT-TQ, NEXN, TNNC1, TPM1 | 10 | |
| Protein synthesis | Elongation of protein | 2.96E-08 | Insulin, MT-TI, MT-TK, MT-TL2, MT-TM, MT-TQ | 6 | |
| Metabolic disease, organismal injury and abnormalities | Mitochondrial disorder | 4.62E-08 | Cytochrome bc1, Mitochondrial complex 1, MT-RNR1, MT-TI, MT-TK, MT-TL2, MT-TM, MT-TQ | 8 | |
| Gene expression, protein synthesis | Translation of mRNA | 7.27E-08 | MT-RNR1, MT-TI, MT-TK, MT-TL2, MT-TM, MT-TQ | 6 | |
| Cardiovascular disease, hereditary disorder, organismal injury and abnormalities, skeletal and muscular disorders | Familial cardiomyopathy | 6.76E-07 | MT-RNR1, MT-TI, NEXN, TNNC1, TPM1 | 5 | |
| Cardiovascular disease, organismal injury and abnormalities, skeletal and muscular disorders | Nonischemic cardiomyopathy | 8.84E-07 | MT-RNR1, MT-TI, NEXN, TNNC1, TPM1 | 5 | |
| Smokers | Metabolic disease, organismal injury and abnormalities | Mitochondrial DNA-related disorder | 5.52E-50 | Mitochondrial complex 1, MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-RNR1, MT-TE, MT-TI, MT-TK, MT-TL1, MT-TL2, MT-TM, MT-TQ, MT-TT, MT-TY | 22 |
| Metabolic disease, neurological disease, organismal injury and abnormalities, skeletal and muscular disorders | Mitochondrial leukoencephalopathy | 4.13E-47 | MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-TE, MT-TI, MT-TK, MT-TL1, MT-TL2, MT-TM, MT-TQ, MT-TT, MT-TY | 20 | |
| Metabolic disease, neurological disease, organismal injury and abnormalities, skeletal and muscular disorders | Mitochondrial cytopathy | 2.13E-43 | Mitochondrial complex 1, MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-TE, MT-TI, MT-TK, MT-TL1, MT-TL2, MT-TM, MT-TQ, MT-TT, MT-TY | 21 | |
| Hereditary disorder, metabolic disease, neurological disease, organismal injury and abnormalities, psychological disorders, skeletal and muscular disorders | MELAS syndrome | 1.3E-39 | MT-CO1, MT-ND1, MT-ND4, MT-ND5, MT-ND6, MT-TE, MT-TI, MT-TK, MT-TL1, MT-TL2, MT-TM, MT-TQ, MT-TT, MT-TY | 14 | |
| Neurological disease, organismal injury and abnormalities | Leukoencephalopathy | 1.31E-38 | ALDH7A1, MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-TE, MT-TI, MT-TK, MT-TL1, MT-TL2, MT-TM, MT-TQ, MT-TT, MT-TY | 21 | |
| Metabolic disease, organismal injury and abnormalities | Mitochondrial disorder | 9.42E-36 | Cytochrome bc1, Mitochondrial complex 1, MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-RNR1, MT-TE, MT-TI, MT-TK, MT-TL1, MT-TL2, MT-TM, MT-TQ, MT-TT, MT-TY | 23 | |
| Developmental disorder, hereditary disorder, metabolic disease, neurological disease, ophthalmic disease, organismal injury and abnormalities, skeletal and muscular disorders | Leber optic atrophy | 5.73E-30 | Mitochondrial complex 1, MT-CO1, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-TL1 | 12 | |
| Hereditary disorder, metabolic disease, neurological disease, organismal injury and abnormalities, skeletal and muscular disorders | Leigh syndrome | 1.31E-28 | MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-TK, MT-TL1 | 13 | |
| Developmental disorder, hereditary disorder, metabolic disease, organismal injury and abnormalities | Mitochondrial respiratory chain deficiency | 5.23E-24 | MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND5, MT-ND6, MT-TE, MT-TL1, MT-TY | 13 | |
| Hereditary disorder, organismal injury and abnormalities, skeletal and muscular disorders | Hereditary myopathy | 1.21E-21 | MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-RNR1, MT-TE, MT-TI, MT-TK, MT-TL1, MT-TL2, MT-TM, MT-TQ, MT-TT, MT-TY | 21 |