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. 2021 Nov 24;6:400. doi: 10.1038/s41392-021-00788-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The specific mechanism of circRNAs and PI3K/AKT pathway in different cancers. a Circ-0072309 sponges miR-100 to inhibit the PI3K/AKT/mTOR pathway in kidney cancer. CircC3P1 inhibits kidney cancer progression via regulation of miR/PTEN pathways and the PI3K/AKT pathway. b Circ0001085 regulates prostate cancer progression through the PI3K/AKT pathway by sponging miR-196b-5p and miR-451a. c Overexpression of circ0002577 enhances the IGF1R/PI3K/AKT axis to increase the migration, invasion, and proliferation of endometrial cancer cells. d CircCSPP1 expression inhibits cervical cancer cell apoptosis and promotes cell proliferation and migration via the miR-361-5p/ITGB1/PI3K/AKT axis in cervical cancer. Image created with BioRender (https://biorender.com/)