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. 2021 Nov 24;6:400. doi: 10.1038/s41392-021-00788-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The mechanism of circRNAs and PI3K/AKT pathway in lung cancer. CircGFRA1 activates the PI3K/AKT pathway by downregulating the expression of miR-188-3p in lung cancer. Circ100876 affects biological functions via PI3K/AKT signaling by regulating the miR-636/RET axis. The circ0018818/miR-767-3p/NID1/PI3K/AKT axis also plays a key role in the progression of lung cancer. Image created with BioRender (https://biorender.com/)