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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2021 May 24;17(1-2):228–241. doi: 10.1007/s11481-021-09999-y

Figure 4. Overexpression of miR-146a reduces glycolysis in rat primary mixed glia.

Figure 4.

Rat primary mixed glia were transfected with a miR-146a overexpression vector and 40 hours after transfection, glycolysis was assessed. All data were analyzed using an ANOVA linear contrast. Glycolysis (A) was significantly reduced in a miR-146a dose-dependent manner (t74 = −12.28, p ≤ 0.0001, R2 = 0.66). Glycolytic capacity (B) was significantly reduced in a dose-dependent fashion (t73 = −9.23, p ≤ 0.0001, R2 = 0.53). Glycolytic reserve (C) was significantly reduced in a dose-dependent manner (t71 = −5.68, p ≤ 0.0001, R2 = 0.30). Data were analyzed by simple linear regression which showed a negative linear trend between the independent variable (miR-146a) and each dependent variable. All data are presented as means ± SEM.