Table 3.
Model inputs: cost parameters such as drug acquisition, drug administration, clinical management, relapse event, drug monitoring, and event adverse used in the base-case model
| Parameter | Value (SE)a | Distribution | Source |
|---|---|---|---|
| Drug acquisition | |||
| Cladribine | $2547 | N/A | Merck Chile [40] |
| Alemtuzumab | $8250 | N/A | MINSAL [45] |
| Natalizumab | $2320 | N/A | |
| Ocrelizumab | $5411 | N/A | |
| Clinical Management by EDSS state (Annualized cost) | |||
| EDSS 0 | $403 ($40) | Gamma | Own elaboration with clinical expert and using EVC 2015 tariffs [46] |
| EDSS 1 | $403 ($40) | Gamma | |
| EDSS 2 | $403 ($40) | Gamma | |
| EDSS 3 | $403 ($40) | Gamma | |
| EDSS 4 | $403 ($40) | Gamma | |
| EDSS 5 | $403 ($40) | Gamma | |
| EDSS 6 | $987 ($99) | Gamma | |
| EDSS 7 | $987 ($99) | Gamma | |
| EDSS 8 | $987 ($99) | Gamma | |
| EDSS 9 | $987 ($99) | Gamma | |
| Drug administration | $218 | Point estimate | |
| Relapse event | |||
| With hospitalization | $1258 (±10%) | Gamma | EVC 2015 [46] |
| w/o hospitalization | $564 (±10%) | Gamma | |
| Drug monitoring | |||
| Biochemistry test | $10 | Point estimate | EVC 2015 [46] |
| Complete blood counts | $8 | Point estimate | |
| HVP test | $81 | Point estimate | UC-FONASA 2017 |
| MRI scan | $98 | Point estimate | EVC 2015 [46] |
| Neurology visit | $14 | Point estimate | |
| Ophthalmology visit | $14 | Point estimate | |
| Thyroid function test | $14 | Point estimate | |
| Tuberculin skin test | $7 | Point estimate | MAI 2018 [24] |
| Urinalysis test with microscopy | $2 | Point estimate | EVC 2015 [46] |
| JC virus test | $99 | Point estimate | UC-FONASA 2017 |
| Adverse event type | |||
| Infusion site reaction | N/A | Own elaboration with clinical expert and using EVC 2015 tariffs [46] | |
| PML | $999 ($100) | Gamma | |
| Severe infection | $841 ($84) | Gamma | |
| Gastrointestinal | $107 ($11) | Gamma | |
| Thyroid-related events | $75 ($8) | Gamma | |
| Influenza-like symptoms | $24 ($2) | Gamma | |
| Malignant tumor | $5380 ($538) | Gamma | |
| Idiopathic thrombocytopenic purpura | $1124 ($112) | Gamma | |
aUnitary costs in US dollars
HVP human papillomavirus, JC John Cunningham, MRI magnetic resonance imaging, N/A not applicable, PML progressive multifocal leukoencephalopathy