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. 2021 Nov;46(6):428–436. doi: 10.30476/ijms.2021.92080.2326

Table 3.

Severe symptoms/complaints of the long COVID syndrome

Clinical Manifestations 3-6 months follow-up, N=2685 6-12 months follow-up, N=1996 P value
Weakness 56 (2%) 33 (1.7%) 0.614
Muscle pain 68 (2.5%) 38 (1.9%) 0.920
Joint pain 65 (2.5%) 45 (2.3%) 0.618
Fatigue 74 (2.8%) 43 (2.2%) 0.825
Sleep difficulty 86 (3.2%) 31 (1.6%) 0.045
Shortness of breath 44 (1.6%) 22 (1.1%) 0.408
Chest pain 13 (0.5%) 7 (0.4%) 0.971
Palpitation 16 (0.6%) 15 (0.8%) 0.294
Cough 10 (0.4%) 12 (0.6%) 0.030
Excess sputum 19 (0.7%) 10 (0.5%) 0.188
Loss of smell 21 (0.8%) 16 (0.8%) 0.136
Loss of taste 11 (0.4%) 7 (0.4%) 0.014
Sore throat 1 (0.03%) 1 (0.05%) 0.891
Headache 40 (1.5%) 22 (1.1%) 0.156
Dizziness 15 (0.6%) 7 (0.4%) 0.740
Brain fog 32 (1.2%) 13 (0.7%) 0.639
Excess sweating 35 (1.3%) 27 (1.4%) 0.185
Exercise intolerance 120 (4.5%) 49 (2.5%) 0.093
Walking intolerance 110 (4.1%) 43 (2.2%) 0.118
Diarrhea 6 (0.2%) 2 (0.1%) 0.719
Abdominal pain 11 (0.4%) 3 (0.2%) 0.309
Anorexia 11 (0.4%) 7 (0.4%) 0.881

After Bonferroni correction, the significant P value is at 0.002