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Scheme for the generation of rat liver fibrosis model and HLSC transplantation. SD rats received biweekly intraperitoneal injections of CCl4 0.65∼1.0 ml/kg for up to 10 weeks. HLSCs were isolated from human liver grafts unsuitable for transplantation, as described in ‘Methods’. Rats underwent abdominal surgery trans-portal HLSC transplantation with simultaneous left hepatic lobectomy.
