Fig. 3.
(A) Changes in fibrosis area following two fibrosis induction protocols. Significant decrease in fibrosis area compared to baseline is seen at 14 weeks after liver fibrosis induction when HLSC transplantation is performed. In the control group, fibrosis area is increased from baseline to week 14 when CCl4 is given with the intense toxicity protocol. In the moderated toxicity protocol, spontaneous regression of liver fibrosis is observed at 14 weeks. (B) Changes in fibrosis area according to transplantation of three HLSC strains. Significant decrease in fibrosis area compared to baseline is seen at 14 weeks after liver fibrosis induction with HLSC7 transplantation. No significant change is seen in the other two HLSC strains. In the control group, fibrosis area is increased from week 10 to week 14. (C) Changes in fibrosis area following three transplantation schemes. Significant decrease in fibrosis area compared to baseline is seen in HLSCx (standard transplantation scheme) 14 weeks after liver fibrosis induction. No significant change is seen in the other two transplant schemes. In the control group, fibrosis area is increased from week 10 to week 14.