Fig. 2.

We experimented the role of CoQ₁₀ in the fibroblasts of SIPS model induced byH₂O₂. GLB1 genes expression encoding the SA-βgal activity is marker of cell senescence. (A) The mRNA level of GLB1 was increased by treatment of H₂O₂ (open bar), and CoQ₁₀ treatment also dose-dependently decreased in fibroblasts of SIPS model. Results are means ± SD. n = 3–7, *p<0.05, **p<0.01. (B) We performed an immunohistochemical analysis of SA-βgal positive, and CoQ₁₀ decreased the number of SA-βgal positive cells of fibroblasts of SIPS model.