Fig. 6.

Proposed scheme for anti-aging effects of CoQ₁₀ in SIPS model. H₂O₂ has been used in various studies as the senescence induction agent, that modeled of SIPS in this study. In this study, SA-βgal activity and SASP synthesis increased in SIPS model of fibroblasts. In addition, increasing of MMP expression levels induced the collagen degradation and decrease of intracellular collagen levels. Furthermore, intracellular ROS levels increased in SIPS model. This change is similar to a well-known phenomenon of replicative senescence in human skin fibroblasts. So, the scheme suggested that CoQ₁₀ could show that anti-aging effects to inhibit ROS that induce SIPS model of fibroblasts.