Table 1.
Clinical characteristics of the study population
| Isolated cytotrophoblast | Control (n = 4) | FGR (n = 5) | p value |
|---|---|---|---|
| Maternal age (years) | 36.3 ± 3.6 | 32.8 ± 6.6 | 0.357 |
| Nulliparity | 1 (25.0%) | 2 (40.0%) | 1.000 |
| Maternal BMI at delivery | 27.0 ± 4.0 | 26.1 ± 5.7 | 0.784 |
| Gestational age at birth (weeks) | 38.6 ± 0.5 | 33.7 ± 5.4 | 0.111 |
| Birth weight (g) | 3,323.5 ± 336.6 | 1,349.4 ± 624.0 | <0.001 |
| Placental weight (g) | 481.8 ± 110.9 | 236.6 ± 138.8 | 0.022 |
| Male newborns | 0 (0.0%) | 3 (33.3%) | 0.167 |
|
| |||
| Immunohistochemistry | Control (n = 13) | PE-FGR (n = 13) | p value |
|
| |||
| Maternal age (years) | 33.3 ± 6.4 | 33.2 ± 3.6 | 0.941 |
| Nulliparity | 7 (53.9%) | 11 (84.6%) | 0.202 |
| Maternal BMI at delivery† | 25.4 ± 4.8 | 23.7 ± 2.4§ | 0.287 |
| Systolic blood pressure (mmHg)† | 118.2 ± 15.8 | 168.5 ± 14.1 | <0.001 |
| Diastolic blood pressure (mmHg)† | 75.5 ± 12.2 | 104.9 ± 8.1 | <0.001 |
| Gestational age at birth (weeks)‡ | 37.7 [32.7–38.7] | 34.1 [27.1–36.4] | <0.001 |
| Birth weight (g)† | 2,803.4 ± 555.2 | 1,387.5 ± 473.8 | <0.001 |
| Placental weight (g)† | 470.8 ± 98.8 | 276.2 ± 101.1 | <0.001 |
| Male newborns | 8 (61.5%) | 9 (69.2%) | 1.000 |
Systolic blood pressures are indicated as the highest value in hospitals for childbirth, and diastolic blood pressures are indicated as the values measured at the same time point. Continuous variables are presented as mean ± SD and p values were calculated by Weltch t test, †Student t test or ‡ as mean [range] by Wilcoxon rank-sum test. Categorical variables are presented as number (percentage) and p values were calculated by Fisher’s exact test. §n = 12 as data was absent.