Table 2.
Multivariable Cox proportional hazards regression analyses for predictors of death in all patients, and patients with and without atrial fibrillation (AF)
| Analysis | All patients (n=165 184) | AF patients (n=12 450) | Non-AF patients (n=152 734) | |||
| Parameters | HR | P value | HR | P value | HR | P value |
| (95% CI) | (95% CI) | (95% CI) | ||||
| CHA2DS2-VASc score | 1.23 (1.21 to 1.25) | <0.001 | 1.21 (1.16 to 1.26) | <0.001 | 1.23 (1.21 to 1.26) | <0.001 |
| Atrial fibrillation | 1.18 (1.10 to 1.27) | <0.001 | N/A | N/A | N/A | N/A |
| Smoking history | 1.65 (1.58 to 1.73) | <0.001 | 1.45 (1.30 to 1.62) | <0.001 | 1.69 (1.61 to 1.77) | <0.001 |
| End-stage renal disease | 2.33 (2.10 to 2.59) | <0.001 | 2.12 (1.71 to 2.64) | <0.001 | 2.43 (2.15 to 2.73) | <0.001 |
| Anticoagulation | 1.50 (1.40 to 1.60) | <0.001 | 1.21 (1.08 to 1.36) | <0.001 | 1.63 (1.51 to 1.77) | <0.001 |
| Aspirin | 1.08 (1.03 to 1.13) | 0.001 | 0.97 (0.86 to 1.09) | 0.569 | 1.08 (1.03 to 1.14) | 0.001 |
| Statin | 0.85 (0.81 to 0.9) | <0.001 | 0.83 (0.74 to 0.94) | 0.003 | 0.86 (0.92 to 0.91) | <0.001 |
| Metabolic equivalents of task | 0.73 (0.72 to 0.74) | <0.001 | 0.74 (0.72 to 0.76) | <0.001 | 0.73 (0.72 to 0.74) | <0.001 |
CHA2DS2-VASc, congestive heart failure, hypertension, age, diabetes mellitus, stroke or transient ischemic attack, vascular disease, sex; N/A, not applicable.