Table. Characteristics of the Vaccinated Populations With MM and Without Cancer (as of October 8, 2021) in the TriNetX Databasea.
| Patient characteristics (fully vaccinated) | Multiple myeloma | Without cancer | P value |
|---|---|---|---|
| Total No. of patients | 1182 | 506 106 | |
| Age, mean (SD), y | 68.0 (11.6) | 51.3 (20.8) | <.001 |
| Gender | |||
| Female | 48.5 | 55.5 | .001 |
| Male | 51.5 | 44.4 | |
| Race and ethnicity, % | |||
| White | 61.4 | 60.4 | .47 |
| Black or African American | 27.5 | 14.9 | <.001 |
| Hispanic or Latino | 6.2 | 13.4 | <.001 |
| Asian | 3.9 | 9.1 | <.001 |
| Unknown | 6.8 | 14.6 | <.001 |
| Comorbidity, % | |||
| Hypertension | 60.2 | 17.8 | <.001 |
| Heart diseases | 22.5 | 3.9 | <.001 |
| Type 2 diabetes | 22.2 | 6.5 | <.001 |
| Overweight or obesity | 19.1 | 7.7 | <.001 |
| Cerebrovascular diseases | 13.8 | 2.7 | <.001 |
| Chronic lung diseases | 21.6 | 6.5 | <.001 |
| Chronic kidney disease | 26.2 | 2.4 | <.001 |
| Liver diseases | 16.2 | 1.9 | <.001 |
| HIV | 1.3 | 0.3 | <.001 |
| Alcohol use | 2.2 | 0.8 | <.001 |
| Tobacco use | 8.5 | 2.3 | <.001 |
| Substance use disorders | 12.6 | 3.2 | <.001 |
| Organ or tissue transplant, % | 25.8 | 0.4 | <.001 |
| Adverse socioeconomic determinants of health, % | 2.8 | 1.1 | <.001 |
| Full vaccination type, % | |||
| Pfizer-BioNTech | 77.0 | 90.1 | <.001 |
| Moderna | 22.2 | 8.5 | <.001 |
| Johnson & Johnson | 0.8 | 1.4 | .12 |
| COVID-related medications, % | |||
| Dexamethasone | 62.1 | 9.3 | <.001 |
| Hydrocortisone | 28.2 | 4.5 | <.001 |
| Ibuprofen | 25.6 | 11.8 | <.001 |
| Methylprednisolone | 40.1 | 13.6 | <.001 |
| Prednisone | 35.6 | 8.3 | <.001 |
| Naproxen | 13.5 | 5.4 | <.001 |
| Remdesivir | 0 | 0.002 | .87 |
| Tocilizumab | 0.9 | 0.06 | <.001 |
| Lopinavir | 0.9 | 0.014 | <.001 |
| Ritonavir | 0.9 | 0.07 | <.001 |
| Imdevimab | 0 | 0.027 | .57 |
a
Demonstrated risk factors for COVID-19 infections or severe outcomes that occurred any time before to the same day as index event of full vaccination are shown. The status of adverse socioeconomic determinants of health was based on the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) code “Persons with potential health hazards related to socioeconomic and psychosocial circumstances” (Z55-Z65), which includes “Problems related to education and literacy” (Z55), “Problems related to employment and unemployment” (Z56), “Occupational exposure to risk factors” (Z57), “Problems related to housing and economic circumstances” (Z59), “Problems related to upbringing” (Z62), among others.