Figure 4.
Interleukin 1 beta (IL1B) was determined to be the most significant inferred upstream regulator of differentially expressed genes in the posttraumatic stress disorder with normal vs high body mass index (PNH) comparison among male subjects. Ingenuity Pathway Analysis software generated a spatial representation of the downstream expression changes observed in 54 target genes in the dataset (P = 1.9 × 10−15) that were mostly upregulated (53 of 54) as a result of IL1B activation; 42 of the relationships associated with activation of IL1B have been empirically observed. Shapes represent the type of molecule. Colors inside the shapes signify regulation of gene expression (red = upregulation; green = downregulation; orange = predicted activation). Line colors signify consistency of the observed relationships with the literature (grey = not predicted; orange = precipitates activation; blue = precipitates inhibition; yellow = observed relationship is not consistent with the state of the downstream molecule).