. 2021 Oct 1;1(11):2080–2087. doi: 10.1021/jacsau.1c00360

Table 2. Substrate Scope for Cyclotrimerization^a.

entry	substrate 1 (Ar)	yield of 2 (%)
1	Ph, 1a	68
2	4-MeC₆H₄, 1b	84
3	3-MeC₆H₄, 1c	77
4	2-MeC₆H₄, 1d	67
5	4-MeOC₆H₄, 1e	86
6	4-BuC₆H₄, 1f	79
7	4-BrC₆H₄, 1g	66^b
8	4-ClC₆H₄, 1h	61^b
9	4-FC₆H₄, 1i	53
10	4-CF₃C₆H₄, 1j	42
11	4-EtO₂CC₆H₄, 1k	46
12	4-MeCOC₆H₄, 1l	39^b
13	4-HOC₆H₄, 1m	71^b
14	4-PhC₆H₄, 1n	49^b
15	2-PhC₆H₄, 1o	42^b
16	3-Py, 1p	0^b
17	1-naphthyl, 1q	41
18	1-octyne (1r)	0
19	(triisopropylsilyl)acetylene (1s)	0
20	1,2-diphenylethyne (1t)	0^b

Reaction conditions: 1 (1 mol equiv., 5 mmol), P4VP-CoCl₂ (0.033 mol %, 330 mol ppm of Co), DIPEA (6.5 mol %), 150 °C, 24 h, N₂ atmosphere. Isolated yield.

One-half a milliliter of xylene was added.

Table 2. Substrate Scope for Cyclotrimerizationa.

Table 2. Substrate Scope for Cyclotrimerization^a.