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. 2021 Nov 24;19:251. doi: 10.1186/s12915-021-01186-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Metabolic pathways present in D. papillatum. Text and arrows in light-gray do not correspond to predicted localizations. Numbers correspond to enzyme numbers in Table 1: 1. glucose oxidase; 2. hexokinase (HK)/glucokinase (GLK); 3. glucose-6-phosphatase (GPase); 4. phosphoglucose-6-isomerase (PGI); 5. pyrophosphate fructose-6-phosphate 1- phosphotransferase (PFP); 6. fructose-1,6-bisphosphatase; 7. fructose-bisphosphate aldolase; 8. glyceraldehyde-3-phosphate dehydrogenase; 9. phosphoglycerate kinase (PGK); 10. phosphoglycerate mutase; 11. enolase (ENO); 12. pyruvate kinase (PK); 13. triosephosphate isomerase; 14. glycerol-3-phosphate dehydrogenase; 15. phosphoenolpyruvate carboxykinase (PEPCK); 16. glucose-6-phosphate dehydrogenase (GPDH); 17. gluconolactonase; 18. 6-phosphogluconate dehydrogenase; 19. ribulose-5-phosphate isomerase; 20. ribulose-5-phosphate epimerase; 21. transketolase, 22. transaldolase; 23. pyruvate carboxylase (PC); 24a. pyruvate dehydrogenase component, E1 (PDH1); 24b. component of 2-oxoglutarate dehydrogenase complex; E2 (PDH2), 24c. dihydrolipoyl dehydrogenase, E3 (PDH3); 25. pyruvate:NADP⁺ oxidoreductase (PNO); 26. lactate dehydrogenase (LDH); 27. opine dehydrogenase; 28. 1-pyrroline-5-carboxylate dehydrogenase; 29. glutamate dehydrogenase; 30. citrate synthase; 31. aconitase (ACO); 32. isocitrate dehydrogenase (IDH); 33. 2-oxoglutarate dehydrogenase; 34. 2-oxoglutarate decarboxylase (OGDC); 35. succinyl-CoA synthetase; 36. succinate-semialdehyde dehydrogenase (SSDH); 37. fumarase; 38. malate dehydrogenase (MDH); 39. malic enzyme (ME); 40. carnitine-acyltransferase; 41. acyl-CoA synthetase (ACS); 42. acyl-CoA dehydrogenase; 43. enoyl-CoA hydratase (ECH); 44. 3-hydroxyacyl-CoA dehydrogenase (HADC); 45. 3-ketoacyl-CoA thiolase (KACT); 46. trifunctional enzyme; 47. acyl-CoA oxidase; 48. bifunctional enzyme; 49. ATP-citrate lyase (ACL); 50. acetyl-CoA carboxylase (ACC); 51. fatty acid synthase, type I (FAS-I); 52. thioesterase. Abbreviations: AOX, alternative oxidase; CoA, coenzyme A; DHAP, dihydroxyacetone phosphate; FRD, fumarate reductase; G3P, glycerol-3-phosphate; G3PDH, glycerol-3-phosphate dehydrogenase; GAP, glyceraldehyde-3-phosphate; I-IV, respiratory complex I-IV; LDH, lactate dehydrogenase; MQ, menaquinone; NDH2, NADH dehydrogenase; ProDH, proline dehydrogenase; UQ, ubiquinone