Fig. 1.

Antiviral activity of AZM and AZM-HCQ combination in a bronchial human airway epithelium (HAE).

Kinetics of virus excretion at the apical side of the epithelium in presence of AZM (a,b) and HCQ-AZM combination (c,d). Kinetics were measured using a TCID₅₀ assay (a,c) and a RT-qPCR assay (b,d). For panels a and b, data represent mean ± SD of two independent experiments each performed in duplicate (n = 4). For panels c and d, data represent mean ± SD of on experiment performed in triplicate (details in Supplemental Table 2). **** and *** symbols indicate that infectious titers or RNA yields are significantly smaller than those for untreated (0 μM AZM) epithelia with a p-value inferior to 0.0001 or ranging between 0.0001 and 0.001, respectively (Multiple comparison t-test) (details in Supplemental Table 3).