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Schematic representation of the loci and affected genes associated with a non-syndromic variant of HGF. Two loci are present on chromosome 2 (GINGF, 2p21-p22 and GINGF3, 2p22.3-p23.3), one on chromosome 4 (GINGF5, 4q12), chromosome 5 (GINGF2, 5q13-q22) and one on chromosome 11 (GINGF4, 11p15). Pathogenic variants of the SOS-1 (Son-of-Sevenless-1) and REST (RE1-silencing transcription factor) genes were associated with GINGF and GINGF5, respectively
