Immune mechanistic parameters from baseline through week 130 by treatment group. A, Peanut-specific IgE. At week 52, the PLB-VP250 group had higher values compared with VP100-VP250 (P = .001) and VP250 (P = .008) groups; at week 130, the VP250 group had higher values compared with PLB-VP250 (P = .002) and VP100–VP250 (P = .008) groups. B, Ara h2 IgE. C, Peanut IgG4. D, Ara h2 IgG4. Overall, the VP250 group had higher values compared with the PLB-VP250 group (P = .005); the VP250 group also had higher values when compared with the VP100–VP250 group (P = .002). A solid black line represents the median, and blue hatched lines represent the upper and lower quartiles. kUA/L, Kilounits of antibody per liter.