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. Author manuscript; available in PMC: 2022 Aug 26.
Published in final edited form as: Adv Funct Mater. 2021 Jun 23;31(35):2103355. doi: 10.1002/adfm.202103355

Figure 4: Growth factors are conserved in an acellular extracellular matrix and create a chemotactic gradient which promotes chondrocyte migration into tissue particles.

Figure 4:

(A, B) Using an established transwell migration assay with four different chemotactic gradients, typically non-migratory chondrocytes demonstrate a significantly greater attraction to the acellular ECM particles than to typical chondrocyte DMEM-F12 media, even with 10% FBS. (C) TGF-β is shown to be highly conserved in the microparticles, despite the processes of decellularization, which likely contributes to the chemotactic influence of the microparticles. (p < 0.05, *compared to DMEM, +compared to 10% FBS).