Table 1: Paclitaxel concentration measurements in patient tumors.

Intratumoral and plasma paclitaxel concentrations were measured by HPLC analysis 20 hours after the first dose of paclitaxel. Paclitaxel was quantified per tumor volume. Paclitaxel was not determined (ND) in the tumor biopsies for patients 5 and 12 due to insufficient tumor tissue collected by biopsy. Patient 10 withdrew consent.

Patient	[plasma paclitaxel, μM]	[Intratumoral paclitaxel, μM]	Degree of concentration
1	0.023	1.07	47x
2	0.040	0.34	9x
3	0.030	0.80	27x
4	0.027	0.57	21x
5	0.031	ND	-
6	0.020	3.43	172x
7	0.013	1.55	119x
8	0.011	0.53	48x
9	0.020	0.63	32x
11	0.038	0.57	15x
12	0.040	ND	-
13	0.094	1.67	18x
14	0.048	0.52	11x
15	0.035	1.20	34x