FIGURE 1.

PET scans over time after administration of 50 μg of ⁸⁹Zr-mesothelin HLE BiTE in 4T1-tumor–bearing mice (n = 8). (A) Representative maximum-intensity projections of PET images up to 9 d after tracer injection. Encircled are spleen (green), heart (red), tumor (blue), and thymus (yellow). (B) Image quantification of heart, tumor, spleen, thymus, and muscle expressed as SUV_mean. (C) Image quantification expressed as organ-to-blood ratios. Data are presented as mean ± SD. MSLN = mesothelin; pi = after injection.