Table 1.
Demographic, antiretroviral therapy (ART) and clinical characteristics at baseline and last paediatric clinic visit by linkage status to the UK Collaborative HIV Cohort (CHIC)
| Total (n = 953) | Linked to UK CHIC (n = 474) | Not linked to UK CHIC (n = 479) | P value | |
|---|---|---|---|---|
| n (%) or median (interquartile range) | ||||
| Demographic and ART baseline | ||||
| Perinatally acquired HIV | 870 (95.9) | 435 (96.2) | 435 (95.6) | 0.63 |
| Female sex | 503 (52.8) | 241 (50.8) | 262 (54.7) | 0.23 |
| Black ethnicity | 738 (77.4) | 380 (80.2) | 358 (74.7) | 0.05 |
| Born abroad | 558 (61.5) | 281 (60.4) | 293 (62.3) | 0.52 |
| Calendar year of birth | 1994 (1991,1996) | 1993 (1990–1995) | 1995 (1992–1997) | < 0.001 |
| Age at HIV diagnosis (years) | 6.6 (2.5–11.0) | 6.0 (2.2–10.7) | 7.3 (3.0–11.1) | 0.05 |
| Started ART in paediatric care | 868 (91.1) | 434 (91.6) | 434 (90.6) | 0.61 |
| Combination ART regimen at ART initiation | 575 (60.3) | 270 (57.0) | 305 (63.7) | 0.04 |
| Age at ART initiation (years) | 8.8 (4.7–12.6) | 8.8 (4.8–12.5) | 8.9 (4.4–12.8) | 0.78 |
| Last paediatric clinic visit | ||||
| Age (years) | 17.7 (16.8–18.5) | 17.7 (16.7–18.5) | 17.7 (16.9–18.4) | 0.99 |
| Calendar year | 2012 (2009–2014) | 2011 (2008–2013) | 2012 (2009–2015) | < 0.001 |
| Nadir CD4 count (cells/μL) | 204 (98–310) | 200 (90–293) | 215 (110–326) | 0.05 |
| CD4 count (cells/μL) | 500 (317–683) | 471 (280–663) | 528 (360–697) | < 0.001 |
| Viral load ≤ 400 copies/mL | 603 (64.2) | 278 (59.9) | 325 (68.4) | 0.007 |
| Prior AIDS event (CDC C) | 247 (25.9) | 131 (27.6) | 116 (24.2) | 0.01 |
| ART status | ||||
| Prescribed ART | 852 (89.4) | 422 (89.0) | 430 (89.8) | 0.71 |
| ART‐naïve/ off ART | 101 (10.6) | 52 (11.0) | 49 (10.6) | |
| Duration in paediatric care (years) | 11.2 (6.9–15.1) | 12.0 (7.4–15.5) | 10.4 (6.4–14.8) | 0.01 |
| Duration between last paediatric and first adult visits (months) | Not known | 3.2 (1.6–6.2) | Not known | |