Table 2.
Rates and risk factors of one or more new AIDS event or mortality in adult care
| Variable | No. of events | Person‐years (PY) | Rate per 100 PY (95% CI) | Unadjusted hazard ratio (95% CI) | P‐value | Adjusted hazard ratio (95% CI) | P‐value |
|---|---|---|---|---|---|---|---|
| A priori | |||||||
| Sex | |||||||
| Male | 13 | 925 | 1.4 (0.8–2.4) | 1 | 1 | ||
| Female | 22 | 1019 | 2.2 (1.4–3.3) | 1.5 (0.8–3.1) | 0.21 | 1.5 (0.7–3.0) | 0.25 |
| Age at HIV diagnosis, per year older | – | – | – | 1.0 (1.0–1.1) | 0.38 | 1.0 (1.0–1.1) | 0.39 |
| Calendar year of last paediatric visit, per year later | – | – | – | 0.9 (0.8–1.0) | 0.002 | 0.9 (0.9–1.0) | 0.14 |
| Demographic | |||||||
| Ethnicity | |||||||
| Black | 31 | 1510 | 2.1 (1.4–2.9) | 1 | |||
| White/other | 4 | 395 | 1.0 (0.4–2.7) | 0.5(0.2–1.4) | 0.18 | ||
| Country of birth | |||||||
| Abroad | 27 | 1142 | 2.4 (1.6–3.4) | 1 | |||
| UK | 8 | 758 | 1.1 (0.5–2.1) | 0.4 (0.2–1.0) | 0.04 | ||
| Last paediatric care visit | |||||||
| CD4 nadir, per 100 cells/μL increase | – | – | – | 0.8 (0.6–1.0) | 0.07 | ||
| CD4 count, per 100 cells/μL increase | – | – | – | 0.8 (0.7–0.9) | 0.002 | 0.8 (0.7–1.0) | 0.03 |
| Viral load > 400 copies/mL in previous year | |||||||
| No | 8 | 7520 | 1.1 (0.5–2.2) | 1 | |||
| Yes | 27 | 1137 | 2.4 (1.6–3.6) | 2.2 (1.0–4.8) | 0.05 | ||
| AIDS diagnosis in paediatric care | |||||||
| No | 16 | 1426 | 1.1 (0.7–1.8) | 1 | 1 | ||
| Yes | 19 | 519 | 3.7 (2.3–5.7) | 3.3 (1.7–6.5) | 0.001 | 2.7 (1.4–5.5) | 0.004 |
| ART status | |||||||
| On ART | 30 | 1658 | 1.8 (1.3–2.6) | 1 | |||
| ART‐naïve/off ART | 5 | 287 | 1.7 (0.7–4.2) | 1.1 (0.4–2.8) | 0.87 | ||
| Gap between last paediatric and first adult visit, per month longer | – | – | – | 1.0 (0.98–1.01) | 0.72 | ||
ART, antiretroviral therapy; CI, confidence interval.