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. 2021 Nov 24;6(6):e00826-21. doi: 10.1128/mSphere.00826-21

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Copyright © 2021 Lin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — IMS analysis showing differentially abundant lipids detected by LC-MS/MS. (A) H&E staining of the gastric mucosae from uninfected and infected animals in the first cohort (left) and the second cohort (right). (B) Overlay of corpus-specific ion 478.2957 on the optical images of tissue sections for the first (left) and second (right) set of tissues. (C and D) The respective ion images show localization of lipids identified by LC-MS/MS at m/z 720.5904 and 790.5718 for the first (left) and the second (right) set of tissues. Black font corresponds to uninfected animals with normal histology, green font indicates infected animals with mild disease (gastritis only), blue font indicates infected animals with dysplasia, and red font indicates infected animals with invasive gastric adenocarcinoma. The figure shows multiple tissue images joined together in an order different from that on the original slides.