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. 2021 Nov 24;2021(11):CD004692. doi: 10.1002/14651858.CD004692.pub5

Comparison 1. n‐3PUFAs vs placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Depressive symptomology (continuous) 33 1848 Std. Mean Difference (IV, Random, 95% CI) ‐0.40 [‐0.64, ‐0.16]
1.2 Adverse events 24 1503 Odds Ratio (M‐H, Random, 95% CI) 1.27 [0.99, 1.64]
1.3 Depressive symptomology (dichotomous ‐ remission) 8 609 Odds Ratio (M‐H, Random, 95% CI) 1.13 [0.74, 1.72]
1.4 Depressive symptomology (dichotomous ‐ response) 17 794 Odds Ratio (M‐H, Random, 95% CI) 1.20 [0.80, 1.79]
1.5 Quality of life 12 476 Std. Mean Difference (IV, Random, 95% CI) ‐0.38 [‐0.82, 0.06]
1.6 Trial non‐completion 29 1777 Odds Ratio (M‐H, Random, 95% CI) 0.92 [0.70, 1.22]