Howe 2008.

Study name	Omega‐3 fatty acid supplementation for symptoms of depression in patients with cardiovascular disease
Methods	Randomised controlled trial, parallel, blinded
Participants	Adults aged between 18 ‐ 75 years with: (a) angiographically‐documented coronary artery disease, defined as > 50% stenosis in an epicardial coronary artery on selective coronary angiography (b) comorbid depression as determined by a score of ≥ 16 on the CES‐D scale
Interventions	Intervention: 4 x 1 g/d capsules of EPA‐rich fish oil for 6 months (each capsule will contain 500 mg EPA and 25 mg DHA) Comparator: 4 x 1 g/d capsules of soybean/corn oil for 6 months (each capsule will contain 500 mg soybean oil and 500 mg corn oil)
Outcomes	Primary: HDRS Secondary: SF‐36; SAQ; flow mediated dilatation in the brachial artery; Changes in cerebral blood flow measured by transcranial Doppler ultrasound Measurements taken at baseline, 3 months (HDRS, SF‐36, SAQ) and 6 months
Starting date	November 2008
Contact information	Professor Peter Howe, Nutritional Physiology Research Centre, University of South Australia
Notes