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. 2021 Nov 24;2021(11):CD004692. doi: 10.1002/14651858.CD004692.pub5

Nakano 2014.

Study name Augmentation of omega‐3 fatty acid with antidepressants for major depressive disorder: a double‐blind, randomised controlled trial
Methods Randomised, double‐blind, parallel‐groups, controlled trial
Participants Adults aged between 20 ‐ 65 years old with a MDE, where: the person did not receive any antidepressant drugs for major depression, has a HDRS (17‐item) score, the major depressive episode is the focus of the treatment and the treating physician has judged escitalopram to be the appropriate first‐line drug, and is a native Japanese speaker
Interventions Intervention: Omega‐3 polyunsaturated fatty acid
Comparator: placebo
Outcomes Primary: HDRS, at 12 weeks
Secondary: MADRS; BDI; QIDS‐J; CGI‐S; RS‐14; Serum BDNF, proBDNF, MMP‐9, fatty acid level; Plasma IL‐6
Starting date April 2014
Contact information Wakako Nakano, University of Occupational and Environmental Health Department of Psychiatry
Notes No working contact details