Nakano 2014.
Study name | Augmentation of omega‐3 fatty acid with antidepressants for major depressive disorder: a double‐blind, randomised controlled trial |
Methods | Randomised, double‐blind, parallel‐groups, controlled trial |
Participants | Adults aged between 20 ‐ 65 years old with a MDE, where: the person did not receive any antidepressant drugs for major depression, has a HDRS (17‐item) score, the major depressive episode is the focus of the treatment and the treating physician has judged escitalopram to be the appropriate first‐line drug, and is a native Japanese speaker |
Interventions | Intervention: Omega‐3 polyunsaturated fatty acid Comparator: placebo |
Outcomes | Primary: HDRS, at 12 weeks Secondary: MADRS; BDI; QIDS‐J; CGI‐S; RS‐14; Serum BDNF, proBDNF, MMP‐9, fatty acid level; Plasma IL‐6 |
Starting date | April 2014 |
Contact information | Wakako Nakano, University of Occupational and Environmental Health Department of Psychiatry |
Notes | No working contact details |