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. 2021 Nov 24;10(13):e12164. doi: 10.1002/jev2.12164

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© 2021 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Large EV s contain classical cellular surfaceome. Venn diagram of total proteins identified in (a). L‐EVs or (b). S‐EVs versus surface proteins reported in CSPA (Bausch‐Fluck et al., 2015), SURFY (Bausch‐Fluck et al., 2018) or UniProt. (c) Voronoi tree maps for L‐EV and S‐EV proteomes generated on wlab.ethz.ch/surfaceome. Light colour indicates low expression; dark colour indicates strong expression. White genes are not expressed. (d) Different classes of SURFY (Bausch‐Fluck et al., 2018) predicted cellular surface proteins identified in each EV‐subtype. (e) Volcano plot of differentially abundant surfaceome proteins in L‐EVs and S‐EVs