TABLE 2.
Percentage Change in Mean Absorbed Dose per Response Category
| Parameter | PD | StD | PR | CR | Trend in P |
|---|---|---|---|---|---|
| Patient level | |||||
| n | 4 | 7 | 12 | 1 | |
| Unadjusted | Reference | 13.6 (−39–112) | 111 (17–281) | — | 0.0087 |
| Adjusted* | Reference | 29 (−19–103) | 58 (5–131) | 0.044 | |
| Tumor level | |||||
| n | 18 | 20 | 37 | 10 | |
| Unadjusted | Reference | −3.5 (−29–31) | 90 (40–161) | 159 (62–286) | <0.001 |
| Adjusted† | Reference | 2 (−16–25) | 74 (42–112) | 94 (47–157) | <0.001 |
*
Adjusted for total tumor volume at baseline (per patient), specific activity and tumor dose heterogeneity, primary tumor location, extrahepatic disease, and number of prior systemic treatment lines.
†
Adjusted for tumor volume at baseline, specific activity, and tumor dose heterogeneity.
Data are in grays, with 95%CIs in parentheses.