Patient examples of classification based on lowest lesion uptake combined with total tumor volume. Maximum-intensity projections are shown without and with delineated tumor volume. Window setting for all images was 0–30. All separate lesions were analyzed individually to obtain minimum SUVmean. (A) Patient in group with high total tumor volume (1.041 cm3) + low minimum SUVmean (9.6); OS, 17 mo; PFS, 11 mo. (B) Patient in group with low total tumor volume (54 cm3) + low minimum SUVmean (13.1); OS, 51 mo; PFS, 42 mo. (C) Patient in group with high total tumor volume (415 cm3) + high minimum SUVmean (25.3); OS, 68 mo; PFS, 34 mo. (D) Patient in group with low total tumor volume (45 cm3) + high minimum SUVmean (15); OS, 118 mo; PFS, 80 mo.