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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Trends Endocrinol Metab. 2021 Apr 13;32(7):415–416. doi: 10.1016/j.tem.2021.03.010

Figure 1. Inhibition of cellular senescence in neovascular tufts suppresses proliferative retinopathy.

Figure 1.

Single-cell RNA sequencing revealed that in mouse oxygen-induced retinopathy (OIR) retinas with pathological angiogenesis, senescence was observed in cells associated with the vascular unit (endothelial cells, pericytes and retinal glia (Müller glia and astrocytes). Increased senescent marker p16INK4a in human retina with proliferative diabetic retinopathy and BCL-xL mouse OIR retina were observed. Inhibition of BCL-xL with UBX1967 to suppress senescence reduced pathological angiogenesis and promoted normal retinal revascularization in mouse OIR retinas.