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. 2021 Nov 24;17(11):e1009877. doi: 10.1371/journal.pgen.1009877

Fig 4. CAB-1 inhibits axon regeneration.

Fig 4

(A) Relative axon length in control animals expressing GABAergic neuron-specific GFP (oxIs12 & juIs76), and rab-27(sa24) and cab-1(tg46) mutants. rab-27 is compared against oxIs12, while cab-1 is compared against juIs76. Axons cut per genotype, L to R: 200, 81, 164, 91. Kolmogorov-Smirnov test was used. ns, not significant, **** p < 0.0001. (B) Relative axon length in control (juIs76) animals, cab-1(tg46) mutants, and animals expressing CAB-1 cDNA under an intestine-specific promoter and stabilized with rab-3 3’ UTR sequence, in both control and cab-1 mutant backgrounds. Number of axons cut per genotype, L to R: 52, 55, 50, 39. Kolmogorov-Smirnov test was used. ns, not significant, ** p < 0.005. (C) Relative axon length in control animals expressing GABAergic neuron-specific GFP (juIs76), rab-27(sa24), aex-4(sa22), cab-1(tg46) mutants and rab-27(sa24); aex-4(sa22) and rab-27(sa24);cab-1(tg46) double mutants. Axons cut L to R: 127, 80, 63, 64, 87, 90. Kolmogorov-Smirnov test was used. ns, not significant, ** p < 0.005. Regeneration was scored after 12 hours of recovery to more easily visualize enhanced regeneration in the rab-27 and rab-27;cab-1 double mutants, which show nearly full regeneration after the usual 24 hour recovery window.