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. 2021 Nov 24;17(11):e1009877. doi: 10.1371/journal.pgen.1009877

Fig 6. Multiple Rab GTPases affect axon regeneration.

Fig 6

(A) Relative axon length in control animals expressing GABAergic neuron-specific GFP (oxIs12 & juIs76), and unc-108/rab-2(n501), rab-3(js49), rab-6.2(ok2254), rab-8(tm2526), rab-10(q373), rab-18(ok2020), rab-19(ok1845), rab-21(gk500186), rab-27(sa24), rab-28(gk1040), and glo-1(zu391). unc-108/rab-2, rab-3, rab-8, rab-10, rab-18, rab-19, rab-21, rab-27 and rab-28 are compared against oxIs12, while rab-6.2 and glo-1 are compared against juIs76. Axons cut per genotype, L to R: 396, 46, 39, 72, 13, 25, 41, 69, 43, 38, 123, 21, 45, 64. Kolmogorov-Smirnov test was used. ns, not significant, * p < 0.05, ** p < 0.005 **** p < 0.0001. (B) Proportion of cut axons showing signs of regeneration in control (juIs76) and glo-1(zu391) mutant animals. Axons cut per genotype, L to R: 32, 45. Unpaired t-test was used. ns, not significant. Error bars represent SEM. (C) Proportion of cut axons showing full regeneration back to the dorsal nerve cord in control (juIs76) and glo-1(zu391) mutant animals. Axons cut per genotype, L to R: 32, 45. Unpaired t-test was used. ns, not significant. Error bars represent SEM.