Table 1. A return to pre-pandemic levels of mobility following vaccination is made infeasible by the presence of vaccine-evading variants.

Scenario	Total infections (millions)	Total fatalities (millions)
Only WT	3.5	0.02
WT + Alpha	148.3	0.85
Alpha + Beta	269.7	1.4
Alpha + Gamma	370.1	1.8
WT + all 3 variants	373.7	1.9

Predicted SARS-CoV-2 infection and mortality burdens over one year upon a return to pre-pandemic levels conditions (R₀ = 3.32), in the United States. The predicted fatalities were calculated using a base infection fatality rate of 0.68% and assuming a 70% reduction in risk of death given infection for vaccinated individuals.